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【转载】Amyotrophic lateral sclerosis and frontotemporal dementia: distinct and overlapping changes in eating behaviour and metabolism  

2016-02-10 13:22:20|  分类: 医学知识 |  标签: |举报 |字号 订阅

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【转载】Amyotrophic lateral sclerosis and frontotemporal dementia: distinct and overlapping changes in eating behaviour and metabolism - liusongjifan2 - liusongjifan2的博客
 
Volume 15, No. 3, p332–342, March 2016
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Amyotrophic lateral sclerosis and frontotemporal dementia: distinct and overlapping changes in eating behaviour and metabolism

Dr Rebekah M Ahmed, MBBScorrespondenceemail
,,,
 Prof Glenda M Halliday, PhD
,
 Prof Lars M Ittner, MD
,
 Prof Sadaf Farooqi, PhD
,
 Prof John R Hodges, MD
,
 Prof Matthew C Kiernan, DSc
Published Online: 25 January 2016
Article has an altmetric score of 29
This article can be found in the following collections: Amyotrophic lateral sclerosisDementias;Neuromuscular disorders

Summary

Metabolic changes incorporating fluctuations in weight, insulin resistance, and cholesterol concentrations have been identified in several neurodegenerative disorders. Whether these changes result from the neurodegenerative process affecting brain regions necessary for metabolic regulation or whether they drive the degenerative process is unknown. Emerging evidence from epidemiological, clinical, pathological, and experimental studies emphasises a range of changes in eating behaviours and metabolism in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). In ALS, metabolic changes have been linked to disease progression and prognosis. Furthermore, changes in eating behaviour that affect metabolism have been incorporated into the diagnostic criteria for FTD, which has some clinical and pathological overlap with ALS. Whether the distinct and shared metabolic and eating changes represent a component of the proposed spectrum of the two diseases is an intriguing possibility. Moreover, future research should aim to unravel the complex connections between eating, metabolism, and neurodegeneration in ALS and FTD, and aim to understand the potential for targeting modifiable risk factors in disease development and progression.

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